Transitional metal ions play a vital role in biological and pharmaceutical fields

Transitional metal ions play a vital role in biological and pharmaceutical fields, and it is evident that many of the organic reagents used in medicine does not possess a pure organic mode of action, many are activated or bio transformed in to metabolites in the presence of inorganic elements. Many organic reagents on coordination with metal ions showed increased pharmacological and toxicological properties. Schiff bases are important class of compounds containing azomethine or imine group which are formed under acids or base catalysis or with heat. The common Schiff base are crystalline solids, which are feebly basic but at least some form insoluble salts with strong acids. Schiff base are used as ligands for preparation of metal complexes having different structures or as intermediates for the synthesis of amino acids. In Schiff base nitrogen of the azomethine group and other donor atoms like oxygen play a very important role in co-ordination chemistry. Hence an attempt is made to study the interaction of reduced Schiff base with transition of metals of biological interest and to investigate the coordination chemistry of such interactions. Schiff bases possess a wide range of biological activity and on coordination with the metal ions to form complexes have shown importance in medicinal and biological fields like antimicrobial 9, 10, anticonvulsant 11, anti-inflammatory 4–7, antioxidant 15, analgesic 5–8, anticancer 13, 14, anthelmintic 16, antitubercular 12, and so forth. Studies enlightened that metal complexes show greater biological activity than free organic compounds 20. Schiff bases are also used as polymer stabilizers 3, intermediates in organic synthesis, catalysts, corrosion inhibitors 19 pigments, and dyes. Augmentation of biological activity was reported by implementation of transition metals into Schiff bases 21. Schiff bases played an important role in development of coordination chemistry and were involved as key point in the development of inorganic biochemistry and optical materials 22. Schiff bases have been utilized as synthons in the preparation of a number of industrial and biologically active compounds like formazans, 4-thiazolidinines, benzoxazines, and so forth, via ring closure, cycloaddition, and replacement reactions 23. Schiff base derivatives in various processes promoted the researchers for designing of novel heterocyclic/aryl Schiff bases for development of new environmental-friendly technology 24. Formation of Schiff base generally takes place under acids or base catalysis or with heat. The common Schiff base are crystalline solids, which are feebly basic but at least some form insoluble salts with strong acids. Schiff base are used as intermediates for the synthesis of amino acids or as ligands for Preparation of metal complexes having a series of different structures. In Schiff base azomethane nitrogen and other donor atoms like oxygen play a vital role in co-ordination chemistry. Hence an attempt is made to study the interaction of reduced Schiff base with transition of metals of biological interest and to investigate the coordination chemistry of such interactions.